New Awards
Agency: Patient Centered Outcomes Research Institute (PCORI)
Title: Colonoscopy versus stool-based testing for older adults with a history of colon polyps (COOP)
Start Date
Period: 04/01/2024-03/31/2026
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Overview:
In a survey of older adults, half preferred FIT, a non-invasive, low cost, stool-based test, to colonoscopy for surveillance of polyps. This approach has not been studied, leading to its absence from major society guidelines. The COOP Trial addresses this evidence gap, as a comparative effectiveness randomized controlled trial (RCT) comparing colonoscopy versus annual FIT for post-polyectomy surveillance among adults aged 65-82 with a history of low-risk colorectal polyps who are due for surveillance colonoscopy within the coming year.
Leslie Morland, PhD
DOD
Title: A Hybrid-1 Effectiveness Implentation Trial of Partner-Assisted Prolonged Exposure for PTSD
Period: 09/30/2024-09/29/2028
Overview:
Partnering with significant others may prove a powerful method for helping Veterans get the most out of their PTSD treatment. The aim of this study is to determine if Partner Assisted Prolonged Exposure (PPE) differs from standard Prolonged Exposure (PE) in its effects on outcomes for intimate partners, including romantic functioning, psychological distress, caregiver burden, and psychosocial functioning.
Victoria Merritt, PhD
DOD
Title: Polygenic Risk Scores (PRS) to Predict Post-Traumatic Epilepsy (PTE) in the Million Veteran Program (MVP) Cohort
Period: 07/01/2025-06/30/2028
Overview:
Post-Traumatic Epilepsy (PTE) is a common complication of traumatic brain injury (TBI), but not all people who survive a TBI develop epilepsy. Thus, if we can predict who is at highest risk for developing PTE, we can design interventions to optimize functional outcomes after TBI and prevent PTE. This study involves phenotyping Veterans with PTE, developing a polygenic risk score (PRS) to predict risk of PTE, and identifying genetic biomarkers of PTE risk.